Successful treatment of patients with Apert syndrome requires an interdisciplinary medical team, including: … Apert Syndrome … Dental problems caused by fusion of teeth sockets. Individuals with Apert syndrome typically have the following conditions: The purpose of this investigation was to study the dental maturation in children with Crouzon or Apert syndrome compared with nonsyndromic controls. There appears to be clinical observations indicating delayed eruption of the permanent teeth in the Apert child. - Dental fusion. Gene mutations are responsible for causing the early fusion of the skull, hand and feet bones. In midface hypoplasia the growth of the top portion of the face, around 2/3rd of it, is anomalous resulting in an unusual look, teeth problems and other illness like sleep apnea. Causes of Apert Syndrome Palate. Hands and feet. Most cases are sporadic. Mutations in the gene encoding fibroblast growth factor receptor 2 (FGFR2), located on chromosome 10, account for almost all known cases . Delayed development and short height. Purpose : Developing teeth are used to assess maturity and estimate age in a number of disciplines. METHODS: This retrospective study examined all Apert syndrome patients from four craniofacial centers who had a panoramic radiograph taken before the age of 16 years. Table 1. Presence of extra finger or fusion of fingers. Apert syndrome (acrocephalosyndactyly type I, MIM #101200) is an autosomal dominant disorder that occurs in 6 to 15.5 out of 1 million livebirths . Knowledge of the most prevalent tooth agenesis patterns may increase our understanding of Apert syndrome by subphenotyping patients with regard to these patterns and by making genotype-phenotype correlations possible.In conclusion, in the present study, the subjects with Apert syndrome were found to exhibit a high prevalence of dental agenesis. Chances of occurrence of Apert syndrome. APERT SYNDROME. Apert syndrome is a genetic disorder, characterized by deformities of the skull, face, and limbs affecting an individual’s health, daily function, and social interaction. Apert syndrome, also called acrocephalosyndactyly, is a genetic syndrome characterized by anomalies of the skull, face and limbs. A child with Apert syndrome also suffers from midface hypoplasia, bicoronal synostosis, and complex syndactyly of the arms and legs. - Ectopic eruption of upper first permanent molars. - About a 1-year dental delay in maturation/eruption in primary and permanent teeth. Ankylosis of teeth Anodontia Apert syndrome Arthrogryposis multiplex congenita whistling face Arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay Atelosteogenesis type 1 Atelosteogenesis type 2 Atelosteogenesis type 3 Auriculo-condylar syndrome - Enamel opacities and/or hypoplasia. - Supernumerary teeth. 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